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Our laboratory uses a combination of structural biology, functional genomics and computational approaches to elucidate the molecular mechanisms and cellular regulation of transcription, the first step in gene expression that governs cell differentiation, embryo development and cancer formation. In my lecture I will provide an overview of our current understanding of the molecular mechanisms underlying gene transcription in eukaryotic cells. I will also provide data that show that transcription is regulated at three key steps, which were revealed by structure-based multiomics analysis.

• Talks